Anders Hansen on 3D Genome Organization

My guest today is Anders Hansen. Anders is an Assistant Professor of Bioengineering at MIT. His group studies the interplay between genome organization and regulation of gene expression in mammals. Anders gives us a deep dive of his research and delves into some very interesting findings from his latest work. 

 

(00:28) -- motivation for studying 3-d genome organization

(1:30) -- tools to study 3d genome organization

(03:44) -- scope of biological question that can be tackled via experimental techniques 

(5:15) -- live cell imaging

(6:30) -- topological features of genome

(9:18) -- genome organization as a function of organism complexity

(11:54) -- mechanism of loop formation in genome

(15:25) -- RNA binding regions and their role in CTCF function

(20:45) -- role of chemistry background in Anders’ research 

(22:55) -- importance of de novo design of genomes